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While suppressed production of inflammatory mediators (IL-12 and IL-23) was attributed to reactive oxygen species or nicotine, stimulation with LPS or CD40 ligand resulted in up-regulation of certain inflammatory mediators (prostaglandin-E2, IL-8, and IL-10) [240,241,242]

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While 86.7% of people continued to use CCs, 3.7% switched completely to ECs, and 9.6% quit completely at follow-up

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